Overview
The root extract (distinct from the leaf) acts on SHBG to free bound testosterone, making more bioavailable free testosterone available to tissues.
Proposed mechanism
Polysaccharides and lectins in nettle root bind to sex hormone-binding globulin (SHBG), preventing SHBG from binding testosterone. Also inhibits 5-alpha-reductase and aromatase.
Mechanisms describe how researchers think a compound may act, often from laboratory work — a proposed mechanism is not proof of a clinical effect in people.
Traditional & studied uses
Hormone ModulationAnti-inflammatory
Related pathways
Endocrine Disruption
Pathway tags are a research aid for browsing the glossary — they are not a claim that this ingredient treats any condition.
Traditional medicine systems
Western Herbalism