Evidence base

Research library

Published research on individual ingredients discussed in our educational materials. These studies examined single compounds — not the Veterans at Ease program — and do not establish that the program produces any clinical outcome. Where evidence is preliminary, animal-only, or from an unrelated population, we say so. Follow the link and read the paper yourself.

AdaptogenicJournal of Alternative and Complementary Medicine · 2018

Efficacy and Safety of Ashwagandha Root Extract in Subclinical Hypothyroid Patients

A small 8-week randomized trial reported changes in thyroid markers among participants with subclinical hypothyroidism. Preliminary, and not replicated at scale. Not a treatment for thyroid disease.

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NeurologicalInternational Journal of Alzheimer's Disease · 2012

Shilajit: A Natural Phytocomplex with Potential Procognitive Activity

Laboratory work reported that fulvic acid can reduce tau aggregation. This was not a human study, and no trial has tested it in traumatic brain injury. It has not been shown to treat, prevent, or reverse TBI.

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HPA AxisIndian Journal of Psychological Medicine · 2012

A Prospective, Randomized Double-Blind, Placebo-Controlled Study of Safety and Efficacy of High Concentration Full-Spectrum Extract of Ashwagandha Root in Reducing Stress and Anxiety in Adults

A randomized, placebo-controlled trial reported reduced self-reported stress and lower serum cortisol after 60 days of high-concentration ashwagandha extract. One trial in a general adult population, not veterans — individual response to adaptogens varies.

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NeurologicalMolecules · 2021

Bacopa monnieri as a Neuroprotective Agent: An Overview

A review of laboratory and animal research on Bacopa's effects on BDNF signalling and antioxidant activity. This is preclinical evidence, not a human trial, and it does not establish that Bacopa treats TBI or cognitive decline in people.

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NeurologicalJournal of Medicinal Food · 2023

Lion's Mane Mushroom Reduces Depression and Anxiety in Overweight or Obese Adults

An 8-week trial in overweight or obese adults reported reduced depression and anxiety scores with Hericium erinaceus supplementation. A single trial in a general population, not veterans, and not specific to PTSD-related anxiety.

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NeurologicalNutrients · 2025

Lion's Mane Mushroom (Hericium erinaceus): A Neuroprotective Fungus with Antioxidant, Anti-Inflammatory, and Antimicrobial Potential — A Narrative Review

A 2025 narrative review describing Lion's Mane's effects on nerve growth factor (NGF) synthesis in laboratory and animal studies — preclinical evidence, not a human trial. No trial has tested it in traumatic brain injury, and it has not been shown to treat or reverse TBI.

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Hormonal HealthJournal of the International Society of Sports Nutrition · 2013

Effect of Tongkat Ali on Stress Hormones and Psychological Mood State in Moderately Stressed Subjects

A 4-week trial in moderately stressed adults reported reductions in cortisol and increases in testosterone with Eurycoma longifolia supplementation. One small trial, not conducted in veterans or on any specific product formulation — not a basis for expecting the same result from any product.

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Hormonal HealthEvidence-Based Complementary and Alternative Medicine · 2013

Clinical Evaluation of Spermatogenic Activity of the Root Extract of Ashwagandha (Withania somnifera) in Oligospermic Males

A trial in men being evaluated for infertility reported increases in sperm count and motility, and changes in testosterone, with ashwagandha root extract. A single trial in a specific clinical population — not evidence of the same effect in a general or veteran population.

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EnergyJournal of Dietary Supplements · 2017

Cordyceps militaris Improves Tolerance to High-Intensity Exercise After Acute and Chronic Supplementation

A trial in healthy adults reported improved VO2 max and exercise tolerance with Cordyceps militaris supplementation. This measured athletic performance, not fatigue related to service or PTSD, and has not been studied in veterans.

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DetoxificationFood and Chemical Toxicology · 2009

Protective Role of Chlorella vulgaris in Lead-Exposed Mice

A study in lead-exposed mice reported reduced blood and organ lead levels with Chlorella vulgaris. This is an animal study, not a human trial, and it does not establish that Chlorella removes heavy metals from the human body. Our products are dietary supplements, not chelation therapy.

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SleepThe American Journal of Medicine · 2006

Valerian for Sleep: A Systematic Review and Meta-Analysis

A meta-analysis of 16 trials found valerian improved subjective sleep-quality ratings, though individual trial results were mixed and objective sleep measures showed less consistent effects. Not studied specifically in veterans or PTSD-related insomnia.

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